Open AccessGenetic polymorphism of methylenetetrahydrofolate-reductase C677T in patients with pseuodarthrosis of the long bones: relationship with the lipid profile and endothelial function
Author(s) -
Yu. O. Bezsmertnyi
Publication year - 2013
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xvii.1.65.2013.2
Subject(s) - methylenetetrahydrofolate reductase , dyslipidemia , reductase , genotype , medicine , gene polymorphism , gastroenterology , gene , genetics , biology , enzyme , obesity , biochemistry
The prevalence of genetic polymorphism of methylenetetrahydrofolate reductase C677T (MTHFR C677T) in 130 patients with pseudoarthrosis of the long bones has been investigated. It has been established that the rate of detecting a defect of the MTHFR C677T gene is 1.4 times higher in patients with impairments of reparative osteogenesis than in patients with consolidated fractures. An abnormal genotype of the MTHFR C677-CT gene was associated with an increase in the share of persons with hypo- and aplastic types of false joints, dyslipidemia and endothelial dysfunction of the central and peripheral vessels.