Open AccessTHE PECULIARITIES OF THE COMBINED COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND CORONARY HEART DISEASE (LITERATURE REVIEW)
Author(s) -
Т. О. Ілащук,
Oksana Mykytyuk,
Ya. V. Chobanu
Publication year - 2021
Publication title -
klìnìčna ta eksperimentalʹna patologìâ
Language(s) - English
Resource type - Journals
eISSN - 2521-1153
pISSN - 1727-4338
DOI - 10.24061/1727-4338.xx.2.76.2021.14
Subject(s) - copd , medicine , pulmonary disease , sirtuin , disease , cardiology , heart failure , oxidative stress , coronary heart disease , sirtuin 1 , inflammation , intensive care medicine , downregulation and upregulation , biochemistry , chemistry , acetylation , gene
The aim – to analyze the literature data sources concerning the peculiarities of thecombined course of chronic obstructive pulmonary disease (COPD) and coronaryheart disease (CHD), taking into account the endothelial dysfunction of systemicinflammation and oxidative stress.Conclusions. The main mechanisms involved in the progression of the combinedcourse of chronic obstructive pulmonary disease and coronary heart disease are theendothelial dysfunction, the systemic inflammation and desynchronosis. The pleiotropiceffects and diverce molecular interactions of sirtuins have distinct physiological effects,such as preventing the development and progression of emphysema in COPD and avoiding the progression of myocardical hypertrophy and heart failure. The researchof intermolecular interactions with the help of Sirtuin is a promising area for findingnew effective diagnostic and prognostic criteria and therapeutic strategies for COPDand CVD.