Open AccessCAUSATIVE-INVESTIGATORY RELATIONSHIPS BETWEEN BOWELS MICROBIOTA AND CLINICAL COURSE OF ISCHEMIA-REPERFUSION DAMAGE OF THE BRAIN
Author(s) -
S. S. Тkachuk,
М. А. Povar,
V. I. Shtefaniuk,
O. V. Tkachuk
Publication year - 2021
Publication title -
klìnìčna ta eksperimentalʹna patologìâ
Language(s) - English
Resource type - Journals
eISSN - 2521-1153
pISSN - 1727-4338
DOI - 10.24061/1727-4338.xix.4.74.2020.17
Subject(s) - ischemia , neuroprotection , damages , brain damage , medicine , neuroscience , brain ischemia , gut flora , immunology , pharmacology , psychology , political science , law
The purpose – to carry out the analysis of the current data concerning relationships inthe “bowels microbiota-brain” system at ischemia-reperfusion damages of the brain.Conclusions.1. The analysis of the literature data testify to the views discrepancy, existing today, on therole of the bowels dysbacteriosis (neuroprotective or neurodegenerative) in the clinicalcourse of ischemic damages of the brain.2. Numerous experimental investigations substantiated the bowels microbiota role:homeostasis derangements of T-cells, which have the determined role in the secondaryneuroinflammation following cerebral ischemia; in the ratio change of their subpopulationsTreg-Th17 and migration of the bowels lymphocytes into the ischemic brain.