Open AccessMORPHOLOGICAL ASSESSMENT OF GESTATION REBUILDING OF THE VASCULAR BED IN THE UNTERINE-PLACENTAL AREA IN CASE OF IRON DEFICIENCY ANEMIA OF PREGNANCY IN THE ASPECT OF CHRONIC PLACENTAL FAILURE
Author(s) -
Olena Tiulienieva,
И. С. Давыденко
Publication year - 2019
Publication title -
klìnìčna anatomìâ ta operativna hìrurgìâ
Language(s) - English
Resource type - Journals
eISSN - 1993-5897
pISSN - 1727-0847
DOI - 10.24061/1727-0847.18.4.2019.7
Subject(s) - anemia , pregnancy , vasculogenesis , gestation , placenta , medicine , fetus , iron deficiency , microangiopathic hemolytic anemia , placental insufficiency , pathology , anatomy , biology , progenitor cell , stem cell , platelet , genetics , thrombotic thrombocytopenic purpura
According to the analysis of the results of own studies, the authors found that in the uterine-placental area during pregnancy with iron deficiency anemia of II-III degrees, there are no adequate gestational changes in 60±0.1 % of the spiral arteries, and insufficiency of venous flow is shown by the decrease of the number of vessels to 4.4±0.22 per 1 mm2 of histologic section area and signs of venous stagnation, mainly in the projection of the peripheral areas of the placenta. For the first time, in order to evaluate gestational immaturity of the uterine-placental region depending on the degree of iron deficiency anemia in the aspect of uterineplacental form of lacuna insufficiency, the technique of immunohistochemical imaging of vimentin in the walls of vessels in the projection of the attachment was applied. The revealed features of immune expression of vimentin in the walls of the spiral arteries in the observations with anemia indicated the preservation of leiomyocytes with incomplete gestational transformation of the arteries. The peculiarities of the concentration of vimentin in the walls of the vessels of the microcirculatory bed reflected the disturbances of the processes of angiogenesis and vasculogenesis in the uterine-placental region with iron deficiency anemia of II - III degrees.