Open AccessAssessment of Immunoreactivity against Therapeutic Options Employing the Leukocyte Adherence Inhibition Test as a Tool for Precision Medicine
Author(s) -
Celso Eduardo Olivier,
Daiana G. Pinto,
Regiane Patussi dos Santos Lima,
Mariana Dias da Silva,
Raquel Acácia Pereira Gonçalves dos Santos,
Ana P. M. Teixeira,
Patrícia Ucelli Simioni
Publication year - 2021
Publication title -
european journal of clinical medicine
Language(s) - English
Resource type - Journals
ISSN - 2736-5476
DOI - 10.24018/clinicmed.2021.2.3.81
Subject(s) - endotype , ovalbumin , medicine , precision medicine , immunology , therapeutic effect , immunotherapy , immune system , allergen , allergy , pharmacology , pathology , asthma
Background: The Precision Medicine’s approach employs the endotype concept as a central feature to personalize medical treatment. Individual immunoreactivity, alongside characteristics such as genetics, environment, and diet, is one of the factors that differentiates the therapeutic-driven endotypes.
Objective: To evaluate the opportunity of the Leukocyte Adherence Inhibition test to differentiate the immunoreactivity between two similar therapeutic agents employed on Allergen Immunotherapy.
Methods: Side by side Leukocyte Adherence Inhibitions tests were performed with ovalbumin and carbamylated ovalbumin on a population of 33 self-reported egg-allergic individuals.
Results: The results showed two endotypes inside the immune response of the studied groups: The first endotype was defined by the 16 individuals that presented a significant decrease in ovalbumin’s immunoreactivity after carbamylation (mean of differences = 35%; p = 0.002). The second endotype was defined by 17 individuals that presented a significant increase in ovalbumin’s immunoreactivity after carbamylation (mean of differences = 32%; p = 0.001).
Conclusion: The Leukocyte Adherence Inhibition test was able to differentiate two distinct immunoreactivity patterns when comparing two similar therapeutic agents suggesting, as proof of concept, a potential role to be employed as a Precision Medicine tool.