Open AccessPersephin as a diagnostic marker of acute brain injury in critically ill newborns: a clinical trial
Author(s) -
А. А. Задворнов,
E. V. Grigoriev
Publication year - 2021
Publication title -
fundamentalʹnaâ i kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2542-0941
pISSN - 2500-0764
DOI - 10.23946/2500-0764-2021-6-3-15-24
Subject(s) - medicine , rank correlation , depression (economics) , brain damage , anesthesia , gastroenterology , machine learning , computer science , economics , macroeconomics
Aim . To study the correlation of serum persephin with clinical, instrumental and biochemical indicators of brain damage and with an adverse outcome in critically ill newborns. Materials and Methods . The study included 44 critically ill newborns. Blood samples were collected on the 1 st and 7 th day of life. Brain injury was assessed by recording Apgar score, depression of consciousness and brainstem reflexes in unsedated patients over 7 days of life, convulsions, neurosonographic signs of cerebral edema, serum protein S100B on the 1 st and 7 th day of life, and using indicators of adverse neurological outcome. The correlation of serum persephin on the 1 st and 7 th day of life with signs of brain damage was evaluated using the Spearman's rank correlation coefficient and Mann-Whitney U-test. Results . No statistically significant correlation was found between the concentrations of serum persephin on the 1 st and 7 th day of life and Apgar score (p = 0.721 and 0.222, respectively), depression of consciousness and stem reflexes (p < 0.05), convulsions (p = 0.673 and 0.432, respectively), cerebral edema (p = 0.737 and 0.558, respectively), and serum protein S100B both on the 1 st day (p = 0.095 and 0.475, respectively) and 7 th day of life (p = 0.988 and p = 0.775, respectively). Further, there was no statistically significant association of the serum persephin on the 1 st day of line with an unfavorable outcome (p = 0.294). Yet, we revealed an association of serum persephin on the 7 th day of life with an unfavorable outcome (p = 0.013), with a cut-off point of 828 ng/mL, a sensitivity of 39%, and a specificity of 100%. Conclusion . Persephin has poor diagnostic and prognostic significance for assessing the severity of brain damage in critically ill newborns. The obtained data on the correlation of the concentration of persephin for 7 days with an unfavorable outcome are doubtful due to the lack of data on its correlation with signs of severe brain damage.