Open AccessPredictors of severe cerebral ischemia in premature infants
Author(s) -
О. В. Ремнева,
Н. И. Фадеева,
Yu.V. Korenovskiy,
Olga V. Kolyado
Publication year - 2019
Publication title -
fundamentalʹnaâ i kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2542-0941
pISSN - 2500-0764
DOI - 10.23946/2500-0764-2019-4-3-15-21
Subject(s) - tbars , medicine , cord blood , thiobarbituric acid , ischemia , glutathione peroxidase , perinatal asphyxia , hypoxia (environmental) , asphyxia , anesthesia , superoxide dismutase , lipid peroxidation , oxidative stress , chemistry , oxygen , organic chemistry
Aim. To identify informative predictors of severe cerebral ischemia in preterm neonates. Materials and Methods . Study sample consisted of 80 preterm infants with intrauterine hypoxia or perinatal asphyxia delivered on the 28th-34th week of gestation. Levels of matrix metalloproteinase-9 (MMP-9) and thiobarbituric acid reactive substances (TBARS) as well as activity of antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase in cord blood plasma of premature infants were evaluated immediately after birth. Results . As compared to other newborns, neonates with severe cerebral ischemia had higher levels of MMP-9 (MMP-9 > 305.6 ng/mL in 14.6% versus 69.7%, respectively) and TBARS in cord blood plasma. Conclusion . MMP-9 and TBARS measured in cord blood plasma of preterm infants may be utilised in diagnostics of severe cerebral ischemia.