Open AccessMolecular genetics of astrocytomas
Author(s) -
Jorge Muñoz,
Xing Fan,
MariadelMar Inda,
Javier S. Castresana
Publication year - 2009
Publication title -
anales del sistema sanitario de navarra
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.175
H-Index - 23
eISSN - 2340-3527
pISSN - 1137-6627
DOI - 10.23938/assn.0773
Subject(s) - pten , astrocytoma , glioblastoma , epidermal growth factor receptor , cancer research , medicine , glioma , oncology , biology , receptor , genetics , signal transduction , pi3k/akt/mtor pathway
Astrocytomas are the most frequent group of intracranial tumors. Among them, glioblastoma is the most aggressive one. In this review we will describe the most common genetic abnormalities found out in astrocytomas. We will refer to the epidermal growth factor receptor (EGFR), p53, p16, PTEN and DMBT1 genes. We will also present certain genetic aspects that influence the progression to glioblastoma.