Analysis of the involvement of the tumour suppressor genes TP53, p16INK4, p21WAF1, RB1 and the drugs metabolizing enzymes in the development of bone tumours in children | Zendy

Ana Patiño-Garcı́a | Zendy; Elena Sotillo | Zendy; Reyes López de Mesa | Zendy; Luis Sierrasesúmaga | Zendy

Open Access

Analysis of the involvement of the tumour suppressor genes TP53, p16INK4, p21WAF1, RB1 and the drugs metabolizing enzymes in the development of bone tumours in children

Author(s) -

Ana Patiño-Garcı́a,

Elena Sotillo,

Reyes López de Mesa,

Luis Sierrasesúmaga

Publication year - 2009

Publication title -

anales del sistema sanitario de navarra

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.175

H-Index - 23

eISSN - 2340-3527

pISSN - 1137-6627

DOI - 10.23938/assn.0728

Subject(s) - gene , cancer research , biology , tumor suppressor gene , osteosarcoma , suppressor , mutation , cell growth , genetics , carcinogenesis

Several tumor suppressor genes such as p16INK4, TP53, RB1 y p21WAF1 are involved in cell cycle regulation in response to DNA damage and belong to the complex pathway that regulates cell proliferation and/or differentiation. We have investigated the presence of mutations in those genes and polymorphisms of Drug Metabolizing Enzymes that could be involved in the development of pediatric bone tumors or in their outcome.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research