Open AccessAnalysis of the involvement of the tumour suppressor genes TP53, p16INK4, p21WAF1, RB1 and the drugs metabolizing enzymes in the development of bone tumours in children
Author(s) -
Ana Patiño,
Elena Sotillo,
Reyes López de Mesa,
Luis Sierrasesúmaga
Publication year - 2009
Publication title -
anales del sistema sanitario de navarra
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.175
H-Index - 23
eISSN - 2340-3527
pISSN - 1137-6627
DOI - 10.23938/assn.0728
Subject(s) - gene , cancer research , biology , tumor suppressor gene , osteosarcoma , suppressor , mutation , cell growth , genetics , carcinogenesis
Several tumor suppressor genes such as p16INK4, TP53, RB1 y p21WAF1 are involved in cell cycle regulation in response to DNA damage and belong to the complex pathway that regulates cell proliferation and/or differentiation. We have investigated the presence of mutations in those genes and polymorphisms of Drug Metabolizing Enzymes that could be involved in the development of pediatric bone tumors or in their outcome.