Open AccessEtiology of schizophrenia: review of genes-ambient interaction
Author(s) -
Jordi Martínez,
M.J. Cuesta,
Víctor Peralta
Publication year - 2009
Publication title -
anales del sistema sanitario de navarra
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.175
H-Index - 23
eISSN - 2340-3527
pISSN - 1137-6627
DOI - 10.23938/assn.0610
Subject(s) - schizophrenia (object oriented programming) , etiology , psychosocial , vulnerability (computing) , psychology , presentation (obstetrics) , psychiatry , medicine , computer science , computer security , radiology
Schizophrenia is a disorder of extraordinary importance and complexity. Heterogeneity in the clinical presentation of schizophrenia is certain, which probably reflects heterogeneity in pathophysiology and etiology. Examination of various risk factors can give clues to the causes. Only genetic risk factors come anywhere near the effect size expected for a strong causal agent in schizophrenia. However, the existence of so many environmental risk factors cannot be ignored. Both psychosocial and biological environmental factors may interact with genetic vulnerability to increase the risk of schizophrenia.