Past and present of monitoring the functional immune response developed against Epstein-Barr and Adenovirus in hematopoietic stem cell transplantation | Zendy

M Vallejo Ruiz | Zendy; Elena Soria Saldise | Zendy; Carlos Puerta | Zendy; Amaya Zabalza | Zendy; Natalia Ramírez | Zendy

Open Access

Past and present of monitoring the functional immune response developed against Epstein-Barr and Adenovirus in hematopoietic stem cell transplantation

Author(s) -

M Vallejo Ruiz,

Elena Soria Saldise,

Carlos Puerta,

Amaya Zabalza,

Natalia Ramírez

Publication year - 2018

Publication title -

anales del sistema sanitario de navarra

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.175

H-Index - 23

eISSN - 2340-3527

pISSN - 1137-6627

DOI - 10.23938/assn.0121

Subject(s) - immunology , immune system , hematopoietic stem cell transplantation , stem cell , cd8 , haematopoiesis , transplantation , cytotoxic t cell , t cell , medicine , disease , biology , hematopoietic stem cell , virology , genetics , biochemistry , in vitro

Epstein-Barr (EBV) and Adenovirus (AdV) viral infections represent a significant cause of morbi-mortality in allogeneic hematopoietic stem cell transplantation recipients due to the use of immunomyelosuppressive treatments and the prolonged period of immunodeficiency that they generate. To date, the post-transplant protective role of EBV and AdV specific CD8+ T lymphocytes (CTLs) has been demonstrated. However, other factors are increasingly important in regulating the reconstitution and activity of CTLs specific to these viruses such as different cell subpopulations (CD4 + T lymphocytes, regulatory T lymphocytes, dendritic cells, Natural Killer cells, etc.), molecular mechanisms of immunoregulation and the drugs administered to the patient as prophylaxis for a possible graft-versus-host disease. The aim of this review is to analyze the importance of monitoring the functional EBV and AdV-specific cellular response in the management of post-transplant recipients.

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