
A importância do equilíbrio entre flexibilidade e estabilidade neuronal na formação de memórias
Author(s) -
Sara Calafate
Publication year - 2021
Publication title -
revistamultidisciplicar.com
Language(s) - English
Resource type - Journals
ISSN - 2184-5492
DOI - 10.23882/ne2146
Subject(s) - neuroscience , hebbian theory , homeostatic plasticity , metaplasticity , flexibility (engineering) , synaptic plasticity , premovement neuronal activity , developmental plasticity , psychology , biology , plasticity , computer science , physics , receptor , artificial neural network , biochemistry , statistics , mathematics , machine learning , thermodynamics
The neurobiological mechanisms behind memory formation remain unknown. Synapses are essential neuronal sub-compartments for the transmission of information within neuronal networks. Hebbian and homeostatic plasticity mechanisms, are two types of processes that play a role on synaptic modifications during the formation of memories. The interaction between these types of plasticity controls the balance between neuronal flexibility and stability to keep neuronal activity within a physiological window. Thus, it is important to better understand these mechanisms and identify the basic units of this system as they may be involved in the onset of neurological disorders. Here, I shed light on the impact of these mechanisms in the early phase of Alzheimer’s disease.