Open AccessPromising Drug Design Strategies: Intrinsically Disordered Proteins
Author(s) -
Catherine Michaux
Publication year - 2020
Publication title -
annals of advanced biomedical sciences
Language(s) - English
Resource type - Journals
ISSN - 2641-9459
DOI - 10.23880/aabsc-16000152
Subject(s) - sequence (biology) , protein structure , function (biology) , intrinsically disordered proteins , computational biology , structure function , drug , protein design , biophysics , chemistry , biology , physics , evolutionary biology , biochemistry , particle physics , pharmacology
In contrast to the classical paradigm “one sequence - one structure - one function” that a given protein sequence corresponds to a well-defined three-dimensional (3D) structure and an associated function, it was discovered in the 1990s that an increasing number of proteins can be functional in the absence of a stable 3D-structure.