Open AccessMOLECULAR MECHANISMS UNDERLYING CANCER CELL RADIORESISTANCE
Author(s) -
Inna Chorna
Publication year - 2022
Publication title -
periodyk naukowy akademii polonijnej
Language(s) - English
Resource type - Journals
eISSN - 2543-8204
pISSN - 1895-9911
DOI - 10.23856/4818
Subject(s) - radioresistance , cell cycle , cancer research , cancer , dna repair , radiation therapy , oncogene , biology , dna damage , cancer cell , tumor microenvironment , cell , medicine , gene , genetics , dna , tumor cells
Radioresistance of the tumor cells remains a significant obstacle for the radiotherapy treatment of cancer. Radioresistance involves multiple genes, factors, and mechanisms that adapt cancer cells or tissues to radiotherapy-induced changes and develop resistance to ionizing radiation. The major studies of the effect of radiation on cells reported include the following areas: 1) the study of DNA damages and their repair; 2) mutations in tumor suppressor genes and radiation-induced oncogene expression; 3) the role of growth factors and cytokines; 4) violation of the cell cycle; 5) elucidation of the mechanisms of apoptosis and necrosis. This review aimed to provide a theoretical basis, which may improve the sensitivity of cancer cells to radiotherapy. It focuses on the roles of tumor metabolism, DNA repair capacity, cell cycle checkpoints, and the tumor microenvironment in the development of radioresistance of cancer cells. Understanding the molecular alterations that lead to radioresistance may provide new diagnostic markers and therapeutic targets to improve radiotherapy efficacy.