Open AccessMODELING THE EFFECTS OF LEAD POLLUTION ON LACTATE DEHYDROGENASE ACTIVITY
Author(s) -
О. О. Коновалова
Publication year - 2019
Publication title -
periodyk naukowy akademii polonijnej
Language(s) - English
Resource type - Journals
eISSN - 2543-8204
pISSN - 1895-9911
DOI - 10.23856/3305
Subject(s) - lactate dehydrogenase , lead acetate , xenobiotic , urea , environmental pollution , pollution , chemistry , lead (geology) , metabolism , energy metabolism , biochemistry , environmental chemistry , toxicity , medicine , toxicology , endocrinology , biology , enzyme , environmental protection , ecology , environmental science , paleontology , organic chemistry
The changes of activity of LDH and its isoenzymatic fractions under load with lead acetate are described. The introduction of a subacute dose of Pb2 + led to a decrease in the LDH activity of the rat liver and an increase in the heart. Preliminary introduction of small doses of Pb2 + partially prevents increased LDH activity in the heart and completely inhibits its increase in the liver. The proportion of urea-stable fraction in the heart and blood serum is significantly increased, indicating an increase in the aerobic direction of energy metabolism. The obtained results are the experimental substantiation of further investigations of influence mechanism of heavy metals on the organism, as well as the motivation to prevent environmental pollution by man-made xenobiotics.