Open AccessKovanaze Intranasal Spray vs Traditional Injected Anesthetics: a Study of Pulpal Blood Flow Utilizing Laser Doppler Flowmetry
Author(s) -
Scott Thayer,
Janice A. Townsend,
Mathilde C. Peters,
Qingzhao Yu,
Mark Odom,
Kent A. Sabey
Publication year - 2022
Publication title -
anesthesia progress
Language(s) - English
Resource type - Journals
eISSN - 1878-7177
pISSN - 0003-3006
DOI - 10.2344/anpr-68-03-10
Subject(s) - medicine , lidocaine , anesthesia , tetracaine , anesthetic , local anesthetic , placebo , topical anesthetic , adverse effect , nasal spray , laser doppler velocimetry , local anesthesia , nasal administration , blood flow , alternative medicine , pathology , immunology
An ideal local anesthetic would be effective, minimally reduce pulpal blood flow (PBF), and not require injection. This study compared the effects of 3% tetracaine plus 0.05% oxymetazoline nasal spray (Kovanaze; KNS) and injections using 2% lidocaine with 1:100,000 epinephrine (LE) or 3% mepivacaine plain (MP) on PBF, anesthetic efficacy, and participant preference.