Open AccessDeterminants of 25-hydroxyvitamin D Status in a Cutaneous Melanoma Population
Author(s) -
Jonathan De Smedt,
Sofie Van Kelst,
Laudine Janssen,
Vivien Marasigan,
Veerle Boecxstaens,
Marguerite Stas,
Dirk Vanderschueren,
Ipek Guler,
Kris Bogaerts,
Katleen Vandenberghe,
Oliver Bechter,
Jaak Billen,
Arjen Nikkels,
Tine Strobbe,
Gabriella Emri,
Diether Lambrechts,
Marjan Garmyn
Publication year - 2022
Publication title -
acta dermato-venereologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.982
H-Index - 83
eISSN - 1651-2057
pISSN - 0001-5555
DOI - 10.2340/actadv.v102.262
Subject(s) - phototype , medicine , vitamin d and neurology , body mass index , population , melanoma , cohort , skin cancer , cancer , oncology , dermatology , environmental health , cancer research
Vitamin D status is influenced by well-known determinants, but factors associated with low 25-hydroxyvitamin D levels in the cutaneous melanoma population are not well defined. The aim of this study was to confirm the well-known determinants and to assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. In a prospectively included cohort of 387 patients with cutaneous melanoma the association of 25-hydroxyvitamin D levels with sex, age, body mass index, time of blood withdrawal, Fitzpatrick phototype, vitamin D supplementation, score for intensity of lifetime sun exposure, smoking, education level, hair and skin colour, eye colour, total number of benign naevi, freckles and parameters of chronic sun damage was investigated. In addition, 25-hydroxyvitamin D levels were correlated with pathological parameters of the primary tumour and melanoma stage (8th edition of the American Joint Committee on Cancer (AJCC). Univariate and multivariate logistic regressions were performed using R software. The following factors had a significant effect on vitamin D status: body mass index, seasonal time of blood sampling, vitamin D supplementation, and a subtype of skin, and hair colour.