Open AccessEvolution of Drug Survival with Biological Agents and Apremilast Between 2012 and 2018 in Patients with Psoriasis from the PsoBioTeq Cohort
Author(s) -
Thomas Bettuzzi,
Debabrata Bandyopadhyay,
M. BeylotBarry,
Hugo Arlégui,
Carle Paul,
Manuelle Viguier,
E. Mahé,
N. Bénéton,
D. Jullien,
M.A. Richard,
P. Joly,
Florence Tubach,
Alain Dupuy,
É. Sbidian,
Olivier Chosidow
Publication year - 2022
Publication title -
acta dermato-venereologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.982
H-Index - 83
eISSN - 1651-2057
pISSN - 0001-5555
DOI - 10.2340/actadv.v101.566
Subject(s) - medicine , psoriasis , hazard ratio , cohort , proportional hazards model , apremilast , drug , cohort study , prospective cohort study , survival analysis , disease , pharmacology , psoriatic arthritis , confidence interval , immunology
Drug survival reflects treatment effectiveness and safety in real life. There is limited data on the variation of drug survival with the availability of systemic treatments with additional biological disease-modifying antirheumatic drugs (bDMARDs) or synthetic disease-modifying antirheumatic drugs (sDMARDs). The aim of this study was to determine whether the increasing number of available systemic treatments for psoriasis affects drug survival over time. Patients were selected from the PsoBioTeq cohort, a French prospective observational cohort enrolling patients with moderate to severe psoriasis. All patients initiating a first bDMARD or sDMARD were included. The primary outcome was comparison of drug survival over time. A multivariate Cox proportional hazard ratio model was computed. A total of 1,866 patients were included; 739 females (39%), median age 47 years. In the multivariate Cox model, no association was found between the calendar year of initiation and drug survival (hazard ratio) overlapping from 0.80 (0.42–1.52) to 1.17 (0.64–2.17), p = 0.633). In conclusion, drug survival in psoriasis is not affected by the year of initiation.