Open AccessEfficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: a Randomized Clinical Trial
Author(s) -
Vicente Navarro-López,
Asunción MartínezAndrés,
A. Ramírez-Boscá,
Beatriz Ruzafa-Costas,
Eva NúñezDelegido,
Miguel A Carrión-Gutiérrez,
David PrietoMerino,
Francisco M. Codoñer-Cortés,
Daniel Ramón-Vidal,
Salvador Genovés-Martínez,
Empar Chenoll,
Jose Manuel Pérez-Orquín,
José Antonio Picó-Monllor,
Sara Chumillas-Lidón
Publication year - 2019
Publication title -
acta dermato-venereologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.982
H-Index - 83
eISSN - 1651-2057
pISSN - 0001-5555
DOI - 10.2340/00015555-3305
Subject(s) - probiotic , placebo , psoriasis , medicine , randomized controlled trial , psoriasis area and severity index , clinical trial , dermatology , pathology , biology , genetics , alternative medicine , bacteria
The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.