Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: a Randomized Clinical Trial | Zendy

Vicente NavarroLópez | Zendy; Asunción MartínezAndrés | Zendy; A. Ramírez-Boscá | Zendy; Beatriz Ruzafa-Costas | Zendy; Eva Núñez-Delegido | Zendy; Miguel A Carrión-Gutiérrez | Zendy; David PrietoMerino | Zendy; Francisco M. Codoñer-Cortés | Zendy; Daniel Ramón | Zendy; Salvador Genovés-Martínez | Zendy; Empar Chenoll | Zendy; Jose Manuel Pérez-Orquín | Zendy; José Antonio Picó-Monllor | Zendy; S Chumillas-Lidón | Zendy

Open Access

Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: a Randomized Clinical Trial

Author(s) -

Vicente NavarroLópez,

Asunción MartínezAndrés,

A. Ramírez-Boscá,

Beatriz Ruzafa-Costas,

Eva Núñez-Delegido,

Miguel A Carrión-Gutiérrez,

David PrietoMerino,

Francisco M. Codoñer-Cortés,

Daniel Ramón,

Salvador Genovés-Martínez,

Empar Chenoll,

Jose Manuel Pérez-Orquín,

José Antonio Picó-Monllor,

S Chumillas-Lidón

Publication year - 2019

Publication title -

acta dermato venereologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.982

H-Index - 83

eISSN - 1651-2057

pISSN - 0001-5555

DOI - 10.2340/00015555-3305

Subject(s) - medicine , probiotic , psoriasis , placebo , randomized controlled trial , psoriasis area and severity index , clinical trial , oral administration , placebo controlled study , dermatology , double blind , pathology , genetics , alternative medicine , bacteria , biology

The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.

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