Open AccessSolar Lentigines are Associated with Better Outcome in Cutaneous Melanoma
Author(s) -
Vivien Marasigan,
Canan Güvenç,
Joost J. van den Oord,
Marguerite Stas,
Veerle Boecxstaens,
Oliver Bechter,
Pascal Wolter,
Diether Lambrechts,
Marjan Garmyn
Publication year - 2019
Publication title -
acta dermato-venereologica
Language(s) - English
Resource type - Journals
eISSN - 1651-2057
pISSN - 0001-5555
DOI - 10.2340/00015555-3270
Subject(s) - medicine , phototype , melanoma , dermatology , population , family history , oncology , skin cancer , cancer , cancer research , environmental health
The rising incidence of cutaneous melanoma and its stable high mortality rates despite innovative cancer care, require better prediction of the clinical outcome. In a large cutaneous melanoma population we explored whether the known clinical risk factors for melanoma susceptibility (nevus phenotype, phototype, family and personal history of melanoma and sun damage) affect melanoma outcomes. A total of 1,530 melanoma patients were included. Multivariable analysis adjusted for age, gender, melanoma stage, localization and subtype showed that familial melanoma, solar lentigines on head and neck, the back of hands, arms and shoulders were associated with a better relapse free survival. The presence of atypical naevi was associated with an increased risk of relapse. After Bonferroni correction, the correlation between presence of solar lentigines on the back of the hands and arms remained the most robust and significant prognostic factor for the relapse free survival in cutaneous melanoma patients.