Open AccessInflammasome Activation Characterizes Lesional Skin of Folliculitis Decalvans
Author(s) -
A. Éyraud,
B. Milpied,
Denis Thiolat,
AnneSophie Darrigade,
Katia Boniface,
Alain Taı̈eb,
Julien Sénéschal
Publication year - 2018
Publication title -
acta dermato-venereologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.982
H-Index - 83
eISSN - 1651-2057
pISSN - 0001-5555
DOI - 10.2340/00015555-2924
Subject(s) - nalp3 , inflammasome , medicine , pathogenesis , scarring alopecia , innate immune system , folliculitis , pathology , immune system , immunology , dermatology , inflammation , scalp
Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and included 17 patients with FD with available biopsies. Disease activity (stable vs. active) was defined clinically and histologically. Immunostaining was performed using antibodies directed against NALP1, NALP3, IL-1β, IL-8, and MxA on FD skin biopsies. Results were compared with normal controls and lichen planopilaris. Eleven patients had active disease and 6 had stable disease. NALP1, NALP3, and IL-1β expression were significantly increased in hair follicles in FD compared with controls and lichen planopilaris. This study highlights the predominant immune signal associated with inflammasome activation in FD, suggesting the use of IL-1β blockade in FD.