Granular C3 Dermatosis | Zendy

Takashi Hashimoto | Zendy; Daisuke Tsuruta | Zendy; Atsushi Yasukochi | Zendy; Hisayoshi Imanishi | Zendy; Hideharu Sekine | Zendy; Teizo Fujita | Zendy; Hideki Wanibuchi | Zendy; Min Gi | Zendy; Sarolta Kárpáti | Zendy; Cassian Sitaru | Zendy; John J. Zone | Zendy; Daisuke Endo | Zendy; Shinichi Abe | Zendy; Tomoya Nishino | Zendy; Takehiko Koji | Zendy; Norito Ishii | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Granular C3 Dermatosis

Author(s) -

Takashi Hashimoto,

Daisuke Tsuruta,

Atsushi Yasukochi,

Hisayoshi Imanishi,

Hideharu Sekine,

Teizo Fujita,

Hideki Wanibuchi,

Min Gi,

Sarolta Kárpáti,

Cassian Sitaru,

John J. Zone,

Daisuke Endo,

Shinichi Abe,

Tomoya Nishino,

Takehiko Koji,

Norito Ishii

Publication year - 2014

Publication title -

acta dermato venereologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.982

H-Index - 83

eISSN - 1651-2057

pISSN - 0001-5555

DOI - 10.2340/00015555-2379

Subject(s) - immunofluorescence , basement membrane , autoantibody , pathology , dapsone , epidermis (zoology) , direct fluorescent antibody , medicine , complement system , immunology , chemistry , antibody , anatomy

There has been no previous systematic study of bullous skin diseases with granular basement membrane zone deposition exclusively of C3. In this study we collected 20 such patients, none of whom showed cutaneous vasculitis histopathologically. Oral dapsone and topical steroids were effective. Various serological tests detected no autoantibodies or autoantigens. Direct immunofluorescence for various complement components revealed deposition only of C3 and C5-C9, indicating that no known complement pathways were involved. Studies of in situ hybridization and micro-dissection with quantitative RT-PCR revealed a slight reduction in expression of C3 in patient epidermis. These patients may represent a new disease entity, for which we propose the term "granular C3 dermatosis". The mechanism for granular C3 deposition in these patients is unknown, but it is possible that the condition is caused by autoantibodies to skin or aberrant C3 expression in epidermal keratinocytes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research