Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14 | Zendy

Sonia Klinger | Zendy; Carine Poussin | Zendy; Marie-Bernard Debril | Zendy; Wanda Dolci | Zendy; Philippe A. Halban | Zendy; Bernard Thorens | Zendy

Open Access

Increasing GLP-1–Induced β-Cell Proliferation by Silencing the Negative Regulators of Signaling cAMP Response Element Modulator-α and DUSP14

Author(s) -

Sonia Klinger,

Carine Poussin,

Marie-Bernard Debril,

Wanda Dolci,

Philippe A. Halban,

Bernard Thorens

Publication year - 2007

Publication title -

diabetes

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.219

H-Index - 330

eISSN - 1939-327X

pISSN - 0012-1797

DOI - 10.2337/db07-1414

Subject(s) - gene silencing , microbiology and biotechnology , cell growth , signal transduction , biology , cancer research , chemistry , biochemistry , gene

Glucagon-like peptide-1 (GLP-1) is a growth and differentiation factor for mature beta-cells and their precursors. However, the overall effect of GLP-1 on increasing beta-cell mass in both in vivo and in vitro conditions is relatively small, and augmenting this effect would be beneficial for the treatment or prevention of type 1 and type 2 diabetes. Here, we searched for cellular mechanisms that may limit the proliferative effect of GLP-1 and tested whether blocking them could increase beta-cell proliferation.

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