Open AccessA Novel Endoscopic Cerenkov Luminescence Imaging System for Intraoperative Surgical Navigation
Author(s) -
Tianming Song,
Xia Liu,
Yao Qu,
Haixiao Liu,
Chengpeng Bao,
Chengcai Leng,
Zhenhua Hu,
Kun Wang,
Jie Tian
Publication year - 2015
Publication title -
molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.815
H-Index - 60
eISSN - 1536-0121
pISSN - 1535-3508
DOI - 10.2310/7290.2015.00018
Subject(s) - optical imaging , preclinical imaging , clinical imaging , in vivo , luminescence , molecular imaging , biomedical engineering , optics , medicine , nuclear medicine , physics , radiology , biology , microbiology and biotechnology
Cerenkov luminescence imaging is an emerging optical technique for imaging the distribution of radiopharmaceuticals in vivo. However, because of the light scattering effect, it cannot obtain optical information from deep internal organs. To overcome this challenge, we established a novel endoscopic Cerenkov luminescence imaging system that used a clinically approved laparoscope and an electron-multiplying charge-coupled device camera. We assessed the performance of the system through a series of in vitro and in vivo experiments. The results demonstrated superior superficial imaging resolution (0.1 mm), a large field of view (500 mm2 with 10 mm imaging distance), and superb imaging sensitivity (imaging 1 μCi) of our system. It captured the weak Cerenkov signal from internal organs successfully and was applied to intraoperative surgical navigation of tumor resection. It offered objective information of the tumor location and tumor residual during the surgical operation. This technique holds great potential for clinical translation