
Estrogenicity of Resin-Based Composites and Sealants Used in Dentistry
Author(s) -
Nicolás Olea,
Rosa Pulgar,
Pilar Pérez,
F. OleaSerrano,
Ana Rivas,
Arantzazu Novillo-Fertrell,
Vicente Pedraza,
Ana M. Soto,
Carlos Sonnenschein
Publication year - 1996
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.2307/3432888
Subject(s) - bisphenol a , sealant , molar , bisphenol , dentistry , methacrylate , saliva , bisphenol s , chemistry , monomer , epoxy , medicine , organic chemistry , polymer , biochemistry
We tested some resin-based composites used in dentistry for their estrogenic activity. A sealant based on bisphenol-A diglycidylether methacrylate (bis-GMA) increased cell yields, progesterone receptor expression, and pS2 secretion in human estrogen-target, serum-sensitive MCF7 breast cancer cells. Estrogenicity was due to bisphenol-A and bisphenol-A dimethacrylate, monomers found in the base paste of the dental sealant and identified by mass spectrometry. Samples of saliva from 18 subjects treated with 50 mg of a bis-GMA-based sealant applied on their molars were collected 1 hr before and after treatment. Bisphenol-A (range 90-931 micrograms) was identified only in saliva collected during a 1-hr period after treatment. The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens