Open AccessNeurobehavioral Aspects of Developmental Toxicity Testing
Author(s) -
Beate Ulbrich,
Anthony K. Palmer
Publication year - 1996
Publication title -
environmental health perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.257
H-Index - 282
eISSN - 1552-9924
pISSN - 0091-6765
DOI - 10.2307/3432662
Subject(s) - developmental toxicity , toxicity , medicine , biology , toxicology , genetics , pregnancy , gestation
Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of animal species and data evaluation. Other problematic areas of study design and conduct, selection of litter representatives for testing, what methods to combine in a resting battery, and statistical treatment of results and their interpretation, will need more research and discussion in the future