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Statistical assessment of multivalued screening tests
Author(s) -
Viana Marios A. G.,
Rogatko André,
Rebbeck Timothy R.
Publication year - 1998
Publication title -
canadian journal of statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.804
H-Index - 51
eISSN - 1708-945X
pISSN - 0319-5724
DOI - 10.2307/3315724
Subject(s) - statistical hypothesis testing , argument (complex analysis) , outcome (game theory) , screening test , range (aeronautics) , statistics , medicine , mathematics , family medicine , engineering , mathematical economics , aerospace engineering
When the outcome of a screening test is expressed by the probabilities of k possible outcomes among individuals with a certain physiologic condition and by the corresponding probabilities among individuals without the condition, the screening usefulness of the test depends on the relative likelihood that its result may properly alter the management of a given patient. New statistical methods are introduced to apply the screening usefulness concept to the assessment of combined or multivalued tests. The method is applied to assess the usefulness of genotypes at cytochrome P450 IAI and glutathione‐S‐transferase‐μ as biomarkers of susceptibility to developing lung cancer. The argument and methods developed should be widely applicable to the statistical assessment of screening tests for a wide range of physiologic conditions.