Premium
A comparison of tests for trend with historical controls in carcinogen bioassay
Author(s) -
Fung Karen Y.,
Krewski D.,
Smythe R. T.
Publication year - 1996
Publication title -
canadian journal of statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.804
H-Index - 51
eISSN - 1708-945X
pISSN - 0319-5724
DOI - 10.2307/3315326
Subject(s) - bioassay , statistics , test (biology) , sample (material) , carcinogen , control (management) , computer science , toxicology , econometrics , mathematics , biology , artificial intelligence , chemistry , paleontology , genetics , chromatography
ABSTRACT Tests for trend in tumour response rates with increasing dose in long‐term laboratory studies of carcinogenicity that take into account historical control information are discussed. The theoretical basis for these tests is described, and their small‐sample properties evaluated using computer simulation. The performance of these tests is also evaluated using data from carcinogenicity experiments conducted under the U.S. National Toxicology Program. Based on these results, recommendations are made as to the most appropriate tests in practice. When the assumptions underlying these tests are satisfied, the use of historical control information is shown to result in an increase in power relative to the classical Cochran‐Armitage test that is widely used without historical controls.