Premium
Analysis of Multivariate Data from Four Dental Clinical Trials
Author(s) -
Geary D. N.,
Huntington E.,
Gilbert R. J.
Publication year - 1992
Publication title -
journal of the royal statistical society: series a (statistics in society)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.103
H-Index - 84
eISSN - 1467-985X
pISSN - 0964-1998
DOI - 10.2307/2982670
Subject(s) - multivariate statistics , multivariate analysis , missing data , clinical trial , normality , multivariate analysis of variance , statistics , covariance , mathematics , random variate , medicine , compositional data , multivariate normal distribution , dentistry , random variable , pathology
SUMMARY Four dental clinical trials conducted between 1974 and 1986 are considered. The trials compare tooth‐pastes, with three or six pastes per trial. Between 1400 and 3000 children enter each trial. Complete data for a given child consist of five oral health variables measured on each of three or four occasions, over a period of 3 years. The complete data are transformed towards multivariate normality. Multivariate analyses of covariance, supplemented by canonical variate coefficients and by estimated marginal means, show up significant effects. Questions arising from missing data are discussed.