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Analysis of Dose–Response Data in the Presence of Extrabinomial Variation
Author(s) -
Boos Dennis D.
Publication year - 1993
Publication title -
journal of the royal statistical society: series c (applied statistics)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.205
H-Index - 72
eISSN - 1467-9876
pISSN - 0035-9254
DOI - 10.2307/2347419
Subject(s) - variation (astronomy) , statistics , mathematics , physics , astrophysics
SUMMARY Binary dose–response data often exhibit extrabinomial variation when the responses arise naturally in groups or litters. This paper investigates the use of generalized Wald and score statistics for robustifying the standard inference methods based on the binomial likelihood. Special attention is given to the probit analysis of a parallel assay of the teratogenic effects on mice of several dioxins.