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Statistical Evaluation of Pharmacopoeia Weight Variation Tests for Tablets Using a Ratio Statistic
Author(s) -
Sengupta Sukalyan
Publication year - 1988
Publication title -
journal of the royal statistical society: series c (applied statistics)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.205
H-Index - 72
eISSN - 1467-9876
pISSN - 0035-9254
DOI - 10.2307/2347313
Subject(s) - statistics , pharmacopoeia , mathematics , econometrics , medicine , pathology , alternative medicine
SUMMARY This paper considers the latest pharmacopoeia weight variation tests and calculates the probabilities of passing such tests using the ratio statistic of the form x i /x̄ where the x i are normally distributed. The probabilities are then compared with those obtained by using the method due to Roberts. Roberts's method leads to underestimates of these probabilities. The results are also used to determine the process conditions to be maintained by a manufacturer to pass the weight variation tests.