Open AccessGut micro flora in genesis of methilthyo metabolites of paracetamol
Author(s) -
Martin Smieško,
Momir Mikov,
P Vera Gusman,
P Maja Djanic
Publication year - 2019
Publication title -
zbornik matice srpske za prirodne nauke
Language(s) - English
Resource type - Journals
eISSN - 2406-0828
pISSN - 0352-4906
DOI - 10.2298/zmspn1937043s
Subject(s) - flora (microbiology) , neomycin , conjugate , gut flora , metabolism , glucuronic acid , cysteine , chemistry , excretion , biochemistry , urinary system , biology , endocrinology , bacteria , genetics , enzyme , antibiotics , polysaccharide , mathematical analysis , mathematics
Gut micro flora represents a system of extensive metabolic capacity which is quite different when compared to other cells of body and organs. In recent times, there has been an evidence of very important role of gut cysteine conjugate beta-lyases in metabolism of cystein conjugates. A lot of studies are dedicated to exploration of the role of gut micro flora in formation of methylthio adducts from paracetamol in conventional mice and those treated with neomycin as our study. A highly significant reduction in urinary excretion of 3-methylthioparacetamol in group of neomycin-treated mice was confirmed as well its glucuronic acid and sulphate conjugates. Following the principal role of gut flora in the C-S cleavage of paracetamol l-3-cyctein it is clear that highest concentration of methylthio adducts from paracetamol are presented in pretreated mice.