Open AccessHeart transplant rejection pathology
Author(s) -
Andrea Stojićević,
Milena Jovanović,
Miloš Matković,
Emilija Nestorović,
Nemanja Stanojevic,
Branko Dožić,
Sofija Glumac
Publication year - 2022
Publication title -
vojnosanitetski pregled
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.123
H-Index - 19
eISSN - 2406-0720
pISSN - 0042-8450
DOI - 10.2298/vsp210716083s
Subject(s) - endomyocardial biopsy , medicine , ejection fraction , transplantation , lung transplantation , biopsy , heart transplantation , cardiology , grading (engineering) , sampling (signal processing) , heart failure , civil engineering , filter (signal processing) , computer science , engineering , computer vision
Baclgrpund/Aim. Heart transplantation is the most effective way to treat patients in the terminal stage of heart failure. Endomyocardial biopsy has proven to be a safe and appropriate technique, with little sampling error and remains to this day one of the most commonly used methods for diagnosing of acute rejection. In 1990, ISHLT defined a standardized system for grading the severity of acute transplant rejection regarding endomyocardial sampling histopathological analysis. The aim of study is assessment of morphological, immunohistochemical and immunofluorescent markers of cellular and antibody-mediated rejection of heart transplant in patients monitored during 2020. Methods. From 31 patients transplanted at the Clinic for Cardiac Surgery of the Clinical Center of Serbia, endomyocardial biopsy material was obtained, then processed and analyzed at the Institute of Pathology of the Medical Faculty, University of Belgrade. Results. The average Transplant Rejection Score (TRS) value was 0.42. Spearman 's correlation test didn?t show a statistically significant relationship between the TRS score value and the difference between the ejection fraction values three and twelve months after transplantation. Conclusion. The mean TRS score value obtained in this study suggests dominant cell graft rejection.