Open AccessThe expression and localization of estrogen receptor beta in hyperplastic and neoplastic prostate lesions
Author(s) -
Aleksandra Fejsa Levakov,
Mihaela Mocko Kaćanski,
Nada Vučković,
Mirjana Živojinov,
Jelena Amidžić,
Jelena Ilić Sabo
Publication year - 2015
Publication title -
vojnosanitetski pregled
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.123
H-Index - 19
eISSN - 2406-0720
pISSN - 0042-8450
DOI - 10.2298/vsp131022069f
Subject(s) - stromal cell , intraepithelial neoplasia , prostate , hyperplasia , prostate cancer , medicine , estrogen receptor beta , estrogen receptor , pathology , estrogen , basal (medicine) , estrogen receptor alpha , high grade prostatic intraepithelial neoplasia , adenocarcinoma , urology , cancer , cancer research , breast cancer , insulin
Benign acini in benign prostatic hyperplasia (BPH) are lined with pseudostratified cylindrical epithelium with a continuous basal cell layer. Adenocarcinoma of the prostate is the most common cancer in men. High gradus-prostatic intraepithelial neoplasia (HGPIN) lesions precede invasive cancer. Prostate adenocarcinoma (PCa) implies a complete absence of basal cells and stromal invasion by malignant acini. Estrogen receptor (ER) is located in nuclei of acinar basal and secretory cells and partially in stromal cells. The aim of this research was to demonstrate and localize ER in BPH and in PCa of different Gleason scores. Considering literature data for ER-beta. expression in different morphologic prostate lesions, it is assumed that there is expression of ER-beta in most moderately differentiated PCa, and that the observed receptor expression is lost with increasing of the Gleason score.