Open AccessAtipical immunophenotype in a littoral cell angioma
Author(s) -
R Colović,
Nada Suvajdžić,
Nikica Grubor,
Nataša Čolović,
Tatjana Terzić
Publication year - 2009
Publication title -
vojnosanitetski pregled
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.123
H-Index - 19
eISSN - 2406-0720
pISSN - 0042-8450
DOI - 10.2298/vsp0901063c
Subject(s) - cd68 , pathology , medicine , cd31 , differential diagnosis , angioma , antigen , immunohistochemistry , cd34 , immunology , vascular disease , biology , stem cell , genetics
Littoral-cell angioma (LCA) is a recently described benign vascular tumor of the spleen, whose imaging and pathologic characteristics have been discussed only by a few authors. The tumor is characterized by a mixture of papillary and cystic areas lined by neoplastic cells deriving from normal splenic lining--littoral cells. The neoplastic LCA cells express both endothelial and histiocytic antigens associated with CD8 negativity, compared with the normal endothelium of the venous sinuses of the spleen red pulp that only expresses endothelial antigens and CD8 positivity. Therefore, the typical and characteristic immunohistochemical pattern of the LCA is as follows: CD31, CD68, CD163, CD21, FVIII antigen positive; CD34, CD8 negative.