Open AccessStaphylococcus aureus methicillin-resistance mechanisms
Author(s) -
Ljiljana Petrovic-Jeremic,
N Kuljić-Kapulica,
Veljko Mirović,
Branislava Kocić
Publication year - 2008
Publication title -
vojnosanitetski pregled
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.123
H-Index - 19
eISSN - 2406-0720
pISSN - 0042-8450
DOI - 10.2298/vsp0805377p
Subject(s) - cefoxitin , staphylococcus aureus , medicine , methicillin resistant staphylococcus aureus , microbiology and biotechnology , penicillin , antibiotics , vancomycin , staphylococcal infections , antibiotic resistance , biology , bacteria , genetics
In many hospitals in the world and in our country, the spread of methicillin-resistant Staphylococcus aureus (MRSA) is so wide that nowdays vancomycin is recommended for empiric treatment of staphylococcal life threatening infections (sepsis, pneumonia) instead of beta-lactam antibiotics. The aim of this study was to determine the production of beta-lactamases in hospital and community isolates of staphyloococus aureus, i.e. hospital associated MRSA (HA-MRSA) and community associated MRSA (CA-MRSA), the presence of homogeneous and heterogeneous type of methicillin resistance, and border-line resistance in Staphylococcus aureus (BORSA). The aim of this study was also to determine if there was a statistically significant difference between mechanisms of resistance in HA-MRSA and CA-MRSA.