Open AccessCerebellar hemangioblastomas: A study of the immunoprofile of neoplastic stromal component
Author(s) -
D Tasić,
D. Dimov,
Miloš Kostov,
S Ilić,
D Dojcinov,
Milan Jovanović,
Goran Stanojević,
Irena Dimov
Publication year - 2004
Publication title -
vojnosanitetski pregled
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.123
H-Index - 19
eISSN - 2406-0720
pISSN - 0042-8450
DOI - 10.2298/vsp0403273t
Subject(s) - stromal cell , pathology , synaptophysin , chromogranin a , cd34 , histogenesis , glial fibrillary acidic protein , hemangioblastoma , vimentin , biology , immunohistochemistry , cancer research , medicine , stem cell , microbiology and biotechnology
Central nervous system hemangioblastomas (HBs) are uncommon, highly vascularized tumors that are predominantly found in the cerebellum. They occur sporadically or in association with von Hippel-Lindau (VHL) disease. HBs are of unknown histogenesis, and the origin of stromal cells is still a subject of debate. The aim of this study was to investigate the immunoprofile of neoplastic stromal component, and to determine whether the profile of the expression of immunomarkers used can contribute to the elucidation of the histogenesis of HBs.