Open AccessClinical efficacy of casein phosphopeptide - amorphous calcium phosphate and casein phosphopeptide-amorphous calcium fluoride phosphate and their influence on the quality of life in patients with Sjögren’s syndrome
Author(s) -
Tamara Perić,
Dejan Marković,
Vesna Tomić Spirić,
Bojan Petrović,
Aleksandra Perić-Popadić,
Evgenija Marković
Publication year - 2020
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh191222041p
Subject(s) - medicine , amorphous calcium phosphate , dentistry , casein , phosphopeptide , calcium , food science , chemistry , kinase , biology , microbiology and biotechnology
/Objective. The purpose of this study was to compare clinical efficacy of casein phosphopeptide ? amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) with 0.05% NaF, and to assess their influence on the quality of life among individuals with Sjogren?s syndrome. Methods. Thirty patients were randomized into three groups treated with different remineralizing agents: CPP-ACP, CPP-ACFP, and 0.05% NaF. Oral health was evaluated at the beginning of the study, after 28 days (short-term effects), and after six months. The diagnosis of dental caries was performed using the decayed, missing, and filled teeth (DMFT) / decayed and filled surfaces (DFS) criteria. Enamel demineralization was visually examined using the white spot lesion index (Gorelick). The gingival health was evaluated with the gingival index (Loe?Silness). Assessment of oral hygiene was done using the simplified oral hygiene index (Greene?Vermilion). The Xerostomia Inventory was used to quantify dry-mouth symptoms. The oral health-related quality of life was analyzed using the short form of the Oral Health Impact Profile (OHIP-14). Results. During the evaluation period, caries increment was not significant. Considerable regression of white spot lesions was noted in all three experimental groups (p < 0.001). No significant improvement in gingival health and oral hygiene was observed. Physical pain was decreased in all three experimental groups, and subjective feeling of dry mouth was reduced in CPP-ACP and CPP-ACFP groups. Conclusion. CPP-ACP and CPP-ACFP may reduce the caries activity and relieve the dry-mouth symptoms in patients with Sjogren?s syndrome.