Open AccessPrognostic significance of new biological markers in chronic lymphocytic leukaemia
Author(s) -
Danijela Leković,
Biljana Mihaljević,
Nada Kraguljac-Kurtović,
Maja Perunčić-Jovanović,
Andrija Bogdanović,
M Čolović,
Mirjana Gotić
Publication year - 2011
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh1112753l
Subject(s) - medicine , cd38 , antigen , immunohistochemistry , clinical significance , beta 2 microglobulin , bone marrow , stage (stratigraphy) , pathology , disease , oncology , gastroenterology , immunology , cd34 , paleontology , genetics , stem cell , biology
Chronic lymphocytic leukaemia is a disease with heterogeneous clinical course and outcome. Some patients have a progressive course of the disease and require therapy immediately after the diagnosis, while others have a stable form without the need for treatment. Recently, two new biological markers, the expression of CD38 antigen and ZAP-70 have shown independent significance in the prognosis in CLL patients.