Open AccessAnaesthesia in children with inherited neuromuscular diseases
Author(s) -
Dušica Simić,
Dragana Bogićević,
Irina Milojević,
Ivana Budić,
Marija Marković
Publication year - 2010
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh1012768s
Subject(s) - medicine , perioperative , malignant hyperthermia , anesthesia , neuromuscular disease , disease , cardiorespiratory fitness , cardiorespiratory arrest , general anaesthesia , intensive care medicine , physical therapy
Children with inherited neuromuscular diseases often require anaesthesia for diagnostic or therapy procedures. These patients have an increased risk of perioperative complications due to the nature of the disease and medications administered during anaesthesia. Many anaesthetics and muscle relaxants can aggravate the underlying disease and trigger life-threatening reactions (cardiorespiratory complications, malignant hyperthermia). Besides, the neuromuscular disorders are associated with atypical and undesirable responses to drugs used during anaesthesia and the perioperative period. The paper presents pathophysiological basis of inherited/genetic neuromuscular diseases and specific anaesthesiological problems. The recommendations are suggested with the aim to make the perioperative course in children optimally safe.