Open AccessLate onset of severe thrombocytopenia during interferon treatment for chronic hepatitis C infection: Case report
Author(s) -
Jelena Hajder,
Nataša Stanisavljević,
Olivera Marković,
Dragomir Marisavljević
Publication year - 2010
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh1004240h
Subject(s) - medicine , platelet , immunology , ribavirin , interferon , autoimmune thrombocytopenia , spleen , bone marrow , hepatitis c virus , hepatitis c , megakaryocyte , splenectomy , purpura (gastropod) , alpha interferon , gastroenterology , virus , stem cell , ecology , haematopoiesis , biology , genetics
Thrombocytopenia is a common finding in chronic liver diseases and it is caused by different pathophysiological mechanisms. Immunologic thrombocytopenic purpura (ITP) in hepatitis C infection is a distinct clinical entity. Possible reasons for ITP in this case could be capabillity of HCV to induce autoimmune phenomena but also immunomodulatory effects of interferon that is used for HCV infection treatment. The specific laboratory parameters for ITP diagnosis during HCV infection have not been defined yet.