Open AccessDetection of bone erosions in knee osteoarthrosis by serum biomarkers
Author(s) -
Sandra Živanović,
Ljiljana Petrović-Rackov,
Milorad Jevtić
Publication year - 2010
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh1002062z
Subject(s) - medicine , osteoarthritis , cartilage , femur , knee joint , subchondral bone , ultrasound , pathology , articular cartilage , urology , surgery , anatomy , radiology , alternative medicine
Osteoarthrosis (OA) is a degenerative chronic disease characterized by destruction of joint articular cartilage and subchondral bone with formation of osteophytes and usuries on joint surface. Quantitative and dynamic changes in remodeling of joint tissue reflect matrix molecules that dismiss as fragments in joint liquid, blood and urine where they can be detected. Human cartilage glycoprotein (YKL-40) is synthesised by chondrocytes and synovial cells and plays a significant role in remodel tissue.