Open AccessThe effect of benfothiamine in the therapy of diabetic polyneuropathy
Author(s) -
Aleksandra Nikolić,
Aleksandra Kačar,
Dragana Lavrnić,
Ivana Basta,
Slobodan Apostolski
Publication year - 2009
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0912594n
Subject(s) - medicine , polyneuropathy , thiamine , diabetes mellitus , combination therapy , diabetic neuropathy , vitamin , vitamin c , anesthesia , gastroenterology , endocrinology
Diabetic polyneuropathy (DPN) is one of the most common diabetic complications, which can result in a significant functional impairment and reduction of the quality of life in affected individuals. It occurs due to alterations in different biochemical mechanisms which require the presence of thiamine, which is why this vitamin is used in the therapy of DPN. Due to the low bioavailability of the hydrosolubile forms of thiamine, its liposolubile preparations (benfotiamine) are preferentially used.