Open AccessImmunoglobulin genes and T-cell receptors as molecular markers in children with acute lymphoblastic leukaemia
Author(s) -
Jelena Lazić,
Lidija Dokmanović,
Nada Krstovski,
Jelica Predojević,
Nataša Tos̆ić,
Sonja Pavlović,
Dragana Janić
Publication year - 2009
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0908384l
Subject(s) - minimal residual disease , medicine , t cell receptor , gene rearrangement , disease , oncology , gene , risk stratification , antibody , immunology , t cell , genetics , biology , leukemia , immune system
Acute lymphoblastic leukaemia (ALL) is a malignant clonal disease, one of the most common malignancies in childhood. Contemporary protocols ensure high remission rate and long term free survival. The ability of molecular genetic methods help to establish submicroscopic classification and minimal residual disease (MRD) follow up, in major percent responsible for relapse.