Open AccessPrognostic significance of cellular vascular endothelial growth factor (VEGF) expression in the course of chronic myeloid leukaemia
Author(s) -
Ana Vidović,
Gradimir Janković,
Dragica Tomin,
Maja Peruničić-Jovanović,
Irena Đjunić,
Vladislava Djurasinovic,
M Čolović
Publication year - 2009
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0908379v
Subject(s) - medicine , angiogenesis , vascular endothelial growth factor , organomegaly , myeloid , bone marrow , immunohistochemistry , neovascularization , immunology , pathology , disease , vegf receptors
Increased angiogenesis in bone marrow is one of the characteristics of chronic myeloid leukaemia (CML), a clonal myeloproliferative disorder that expresses a chimeric bcr/abl protein. Vascular endothelial growth factor (VEGF) is one of the most potent and a specific regulator of angiogenesis which principally targets endothelial cells and regulates several of their functions, including mitogenesis, permeability and migration. The impact of elevated VEGF expression on the course of chronic myeloid leukaemia is unknown.