Open AccessNeurotoxicity during induction treatment of childhood acute lymphoblastic leukaemia: Two case reports
Author(s) -
Gordana Kostić,
Danijela Jovancic,
Ljiljana Šaranac,
Bojko Bjelaković
Publication year - 2009
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0906266k
Subject(s) - medicine , neurotoxicity , pediatrics , toxicity
During chemotherapy of acute lymphoblastic leukaemia (ALL), children sometimes exhibit neurological disturbances. Chemiotherapeutic regimens include methotrexate, administered either intravenously or via intrathecal route. Although multiple drugs are used in addition to methotrexate, the acute neurotoxicity reported in patients is usually attributed to methotrexate. The acute neurotoxicity usually results in stroke-like symptoms such as aphasia, weakness, sensory deficits, ataxia and seizures.