Open AccessAlterations of c-Myc and c-erbB-2 genes in ovarian tumours
Author(s) -
Tibor J. Pastor,
Branka Popović,
Ana Gvozdenovic,
Aleksandar Boro,
Bojana Petrović,
Ivaovaković,
Dragana Puzović,
Ljiljana Luković,
Jelena Milašin
Publication year - 2009
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0902047p
Subject(s) - gene duplication , ovarian cancer , cancer research , ovarian carcinoma , gene , medicine , cancer , erbb , oncogene , biology , cell cycle , genetics
According to clinical and epidemiological studies, ovarian cancer ranks fifth in cancer deaths among women. The causes of ovarian cancer remain largely unknown but various factors may increase the risk of developing it, such as age, family history of cancer, childbearing status etc. This cancer results from a succession of genetic alterations involving oncogenes and tumour suppressor genes, which have a critical role in normal cell growth regulation. Mutations and/or overexpression of three oncogenes, c-erbB-2, c-Myc and K-ras, and of the tumour suppressor gene p53, have been frequently observed in a sporadic ovarian cancer.