Open AccessImportance of genotyping of Thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy
Author(s) -
Lidija Dokmanović,
Dragana Janić,
Nada Krstovski,
Branka Zukić,
Nataša Tos̆ić,
Sonja Pavlović
Publication year - 2008
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0812609d
Subject(s) - thiopurine methyltransferase , medicine , genotype , genotyping , gastroenterology , pediatrics , azathioprine , gene , genetics , disease , biology
Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyses the inactivation of mercaptopurine (MP) which is widely used in the treatment of acute lymphoblastic leukaemia (ALL) of childhood. Potentially fatal myelotoxicity may develop after standard doses of MP in TPMT deficient patients.