Open AccessCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): Three case reports from Serbia
Author(s) -
Jasna Zidverc-Trajković,
Vesna Lačković,
Aleksandra Pavlović,
Miloš Bajčetić,
Zvonko Carevic,
Gordana Tomić,
Gorana Mandić,
Milija Mijajlović,
Ž. Jovanović,
Nadežda Šternić
Publication year - 2008
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0804148z
Subject(s) - cadasil , leukoencephalopathy , medicine , pathology , neuroscience , disease , biology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy leading to recurrent strokes and vascular dementia in young and middle-aged patients. The diagnosis of CADASIL is based on typical clinical presentation and characteristic magnetic resonance imaging (MRI) changes, and has to be confirmed by biopsy of the sural nerve, muscle and skin, as well as by genetic analysis. Mutations within the Notch3 gene were identified as the underlying genetic defect in CADASIL.