
HIV infection and the kidneys, Part II: Morphologic changes and their diagnostic significance
Author(s) -
Gordana Basta-Jovanović,
Sanja Radojević,
Marina Savin,
Tatjana Terzić,
Maja Nenadović,
Biljana Stojimirović,
Stevo Škodrić,
Vladimir Nešić,
Steve Dikman
Publication year - 2005
Publication title -
srpski arhiv za celokupno lekarstvo
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.135
H-Index - 17
eISSN - 2406-0895
pISSN - 0370-8179
DOI - 10.2298/sarh0506258b
Subject(s) - medicine , focal segmental glomerulosclerosis , glomerulopathy , pathology , human immunodeficiency virus (hiv) , nephropathy , immunofluorescence , glomerulosclerosis , glomerulonephritis , kidney , immunology , proteinuria , antibody , diabetes mellitus , endocrinology
HIV-infected patients may be faced with a variety of renal problem patterns. HIV-associated nephropathy is a unique pattern of sclerosing glomerulopathy and represents the most rapidly progressive form of focal segmental glomerulosclerosis. This study involved the examination of 32 renal biopsies: by light, immunofluorescence, and electron microscopy, in order to determine the most accurate and reliable diagnostic procedure. The findings show that the most sensitive and accurate procedure is electron microscopy, capable of detecting specific EM changes very early on, which is sufficient for the diagnosis of HIV-associated nephropathy.